Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders.

@article{Urraca2015CharacterizationON,
  title={Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders.},
  author={Nora Urraca and Rawaha Memon and Ikbale El-Iyachi and Sarita Goorha and Colleen Valdez and Quynh T. Tran and Reese S. Scroggs and Gustavo A Miranda-Carboni and Martin Donaldson and Dave Bridges and Lawrence T. Reiter},
  journal={Stem cell research},
  year={2015},
  volume={15 3},
  pages={722-730}
}
A major challenge to the study and treatment of neurogenetic syndromes is accessing live neurons for study from affected individuals. Although several sources of stem cells are currently available, acquiring these involve invasive procedures, may be difficult or expensive to generate and are limited in number. Dental pulp stem cells (DPSCs) are multipotent stem cells that reside deep the pulp of shed teeth. To investigate the characteristics of DPSCs that make them a valuable resource for… CONTINUE READING

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Dental pulp stem cells ( DPSCs ) are multipotent stem cells that reside deep the pulp of shed teeth .
Dental pulp stem cells ( DPSCs ) are multipotent stem cells that reside deep the pulp of shed teeth .
Gene ExpressionProcess includes biological processGenetic Translation Process
To investigate the characteristics of DPSCs that make them a valuable resource for translational research , we performed a set of viability , senescence , immortalization and gene expression studies on control DPSC and derived neurons .
We immortalized control DPSCs using human telomerase reverse transcriptase ( hTERT ) and evaluated neuronal differentiation potential and global gene expression changes by RNA - seq .
We immortalized control DPSCs using human telomerase reverse transcriptase ( hTERT ) and evaluated neuronal differentiation potential and global gene expression changes by RNA - seq .
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