Characterization of neural cell adhesion sites: point contacts are the sites of interaction between integrins and the cytoskeleton in PC12 cells.

@article{Arregui1994CharacterizationON,
  title={Characterization of neural cell adhesion sites: point contacts are the sites of interaction between integrins and the cytoskeleton in PC12 cells.},
  author={Carlos O. Arregui and Salvatore Carbonetto and Lisa J. McKerracher},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 11 Pt 2},
  pages={6967-77}
}
As developing or regenerating neurons grow, their axons seek cues in the extracellular matrix that are recognized by integrin receptors. To understand the regulation and structure of neural integrin complexes, we have examined the association of two functionally important integrins, alpha 1 beta 1 and alpha 3 beta 1, within PC12 cells. Detergent-resistant cytoskeletal ghosts were prepared from PC12 cells and examined by immunoblotting. In cells maintained in suspension the alpha 1, alpha 3, and… CONTINUE READING