Characterization of natural antimony resistance in Leishmania donovani isolates.

  title={Characterization of natural antimony resistance in Leishmania donovani isolates.},
  author={Mukul K Mittal and Smita Rai and Ashutosh and Ravinder and Suman Gupta and Shyam Sundar and Neena Goyal},
  journal={The American journal of tropical medicine and hygiene},
  volume={76 4},
Clinical resistance to pentavalent antimonial compounds has long been recognized as a major problem in the treatment of visceral leishmaniasis in India. However, mechanisms of natural resistance are unclear. In this study, we observed that Leishmania donovani clinical isolates not responsive to sodium stibogluconate showed resistance to antimony treatment in both in vitro and in vivo laboratory conditions. The resistant isolates have increased levels of intracellular thiols. This increase in… CONTINUE READING
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New mechanisms of drug resistance in parasitic protozoa.

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