Characterization of natural antimony resistance in Leishmania donovani isolates.

@article{Mittal2007CharacterizationON,
  title={Characterization of natural antimony resistance in Leishmania donovani isolates.},
  author={Mukul K Mittal and Smita Rai and Ashutosh and Ravinder and Suman Gupta and Shyam Sundar and Neena Goyal},
  journal={The American journal of tropical medicine and hygiene},
  year={2007},
  volume={76 4},
  pages={
          681-8
        }
}
Clinical resistance to pentavalent antimonial compounds has long been recognized as a major problem in the treatment of visceral leishmaniasis in India. However, mechanisms of natural resistance are unclear. In this study, we observed that Leishmania donovani clinical isolates not responsive to sodium stibogluconate showed resistance to antimony treatment in both in vitro and in vivo laboratory conditions. The resistant isolates have increased levels of intracellular thiols. This increase in… CONTINUE READING
Highly Cited
This paper has 96 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs

International journal for parasitology. Drugs and drug resistance • 2018
View 4 Excerpts
Highly Influenced

97 Citations

051015'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 97 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 49 references

New mechanisms of drug resistance in parasitic protozoa.

Annual review of microbiology • 1995
View 4 Excerpts
Highly Influenced