Characterization of myeloid or lymphoid acute leukemia by a chemiluminescence assay. Comparison with immunocytochemistry using an antimyeloperoxidase antibody.

@article{Fonseca1993CharacterizationOM,
  title={Characterization of myeloid or lymphoid acute leukemia by a chemiluminescence assay. Comparison with immunocytochemistry using an antimyeloperoxidase antibody.},
  author={Luiz Marcos da Fonseca and Iguatemy Lourenço Brunetti and Eduardo M Rego and Aglair Bergamo Garcia and Giuseppe Cilento and Roberto Passetto Falc{\~a}o},
  journal={Acta haematologica},
  year={1993},
  volume={90 1},
  pages={19-24}
}
A simple and sensitive chemiluminescence assay for the demonstration of the activity of intracellular myeloperoxidase (MPO) is described, which is useful for the distinction between myeloid and lymphoid commitment in blasts from acute leukemia patients. When the cut-off point was settled at 13 mV of chemiluminescence all cases of acute myeloid leukemia (AML) were distinguished from those of acute lymphoid leukemia. In addition, this technique was able to demonstrate MPO activity in AML poorly… CONTINUE READING