Characterization of muscarinic cholinergic receptor subtypes in human peripheral lung.

@article{Bloom1988CharacterizationOM,
  title={Characterization of muscarinic cholinergic receptor subtypes in human peripheral lung.},
  author={John W. Bloom and Marilyn J. Halonen and Henry I. Yamamura},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={244 2},
  pages={625-32}
}
The authors have characterized the muscarinic cholinergic receptor subtypes in human peripheral lung membranes using the selective muscarinic antagonist [3H]pirenzepine [( 3H]PZ) and the classical muscarinic antagonist [3H](-)-quinuclidinyl benzilate. High-affinity binding with pharmacologic specificity was demonstrated for both radioligands. The high affinity Kd for [3H]PZ binding determined from saturation isotherms was 5.6 nM, and the Kd for [3H](-)-quinuclidinyl benzilate binding was 14.3… CONTINUE READING