Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

@article{Fendly1990CharacterizationOM,
  title={Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.},
  author={Brian M. Fendly and Marcy D. Winget and Robert M. Hudziak and Michael T. Lipari and Mary A. Hepburn John D. Napier and Axel Ullrich},
  journal={Cancer research},
  year={1990},
  volume={50 5},
  pages={1550-8}
}
High levels of expression of either the epidermal growth factor receptor or the receptor-like HER2/neu gene product p185HER2 have been observed in a variety of human malignancies. Because of the association of this high level expression with certain human tumors, we have generated a panel of monoclonal antibodies specific for either the epidermal growth factor receptor or p185HER2 to study their structure, function, and antigenic domains in the normal and neoplastic states. We used the… CONTINUE READING