Characterization of mother-infant HIV type 1 gag p17 sequences associated with perinatal transmission.

@article{Hahn1999CharacterizationOM,
  title={Characterization of mother-infant HIV type 1 gag p17 sequences associated with perinatal transmission.},
  author={Tobias Hahn and E Matala and Colombe Chappey and Navid Ahmad},
  journal={AIDS research and human retroviruses},
  year={1999},
  volume={15 10},
  pages={875-88}
}
The gag p17 matrix sequences of human immunodeficiency virus type 1 (HIV-1) from seven infected mother-infant pairs were analyzed after perinatal transmission. The p17 matrix open reading frame was maintained in 143 of the 166 clones analyzed (86.2% frequency of intact p17 open reading frames). The functional domains essential for p17 matrix function in HIV-1 replication, including targeting of Gag to the plasma membrane, virus assembly and release, envelope glycoprotein incorporation into… CONTINUE READING

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