Characterization of monoclonal antibody epitope specificity using Biacore’s SPR technology

  • N O T E
  • Published 2002

Abstract

Epitope mapping using monoclonal antibodies (MAbs) is a powerful tool in examining the surface topography of macromolecules. Through its binding, each MAb defines one specific site, or epitope, on the antigen, and a pair of MAbs which bind to closely situated epitopes will interfere sterically with each other’s binding [1,2,3]. Determination of epitope… (More)

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