Characterization of monoclonal antibodies for prostate-specific antigen and development of highly sensitive free prostate-specific antigen assays.

Abstract

BACKGROUND The recent elucidation of the importance of serological free prostate-specific antigen (PSA) in the diagnosis of prostate cancer has created a demand for immunoassays specific for free PSA. METHODS We developed and characterized 11 monoclonal antibodies with high affinities for PSA (Ka values from 1.1 x 10(8) to 1.8 x 10(10)L/mol), only 3 of… (More)

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@article{Black1999CharacterizationOM, title={Characterization of monoclonal antibodies for prostate-specific antigen and development of highly sensitive free prostate-specific antigen assays.}, author={Margot H. Black and Christian Grass and Jari T Leinonen and U. H. Stenman and Eleftherios P Diamandis}, journal={Clinical chemistry}, year={1999}, volume={45 3}, pages={347-54} }