Characterization of mitochondrial ferritin-deficient mice.

@article{Bartnikas2010CharacterizationOM,
  title={Characterization of mitochondrial ferritin-deficient mice.},
  author={Thomas B Bartnikas and Dean R Campagna and Brendan Antiochos and Howard L Mulhern and Corinne Pondarr{\'e} and Mark D Fleming},
  journal={American journal of hematology},
  year={2010},
  volume={85 12},
  pages={958-60}
}
Acute promyelocytic leukemia (APL) represents a subset of AML with t(15;17), responsiveness to ATRA, and a favorable prognosis, yet the impact of FLT3ITD mutations over wild-type (wt)FLT3 remains unclear. We retrospectively analyzed the outcome of 26 APL patients treated at our center according to their FLT3 receptor mutation status. We show that APL patients with an ITD mutation (n 5 9) have a lower fibrinogen at presentation (103.5 vs. 235 mg/dl, p 5 0.04) and a worse disease free survival… CONTINUE READING

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