Characterization of microglial attachment and cytokine release on biomaterials of differing surface chemistry.

@article{Leung2008CharacterizationOM,
  title={Characterization of microglial attachment and cytokine release on biomaterials of differing surface chemistry.},
  author={B. P. K. Leung and Roy Biran and Clay J Underwood and Patrick A. Tresco},
  journal={Biomaterials},
  year={2008},
  volume={29 23},
  pages={3289-97}
}
The clinical usefulness of central nervous system recording electrodes is currently limited by inconsistent long-term performance that is believed to be governed by the brain tissue response to the implant. In this study, we observed persistent macrophage biomarker expression at the biotic-abiotic interface surrounding implanted electrodes over a 12-week indwelling period. Using the cell type-specific marker CD11b to examine the cells attached to electrodes retrieved over the indwelling period… CONTINUE READING
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Chronic tissue reaction surrounding planar microelectrode arrays is associated with inflammation and neuronal loss in the recording zone

  • XK Chen, TP Williamson, BK Leung, AL Pollock, PA Tresco
  • 36 th Annual meeting for the society for…
  • 2006

Chronic tissue reaction surrounding planar microelectrode arrays is associated with inflammation and neuronal loss in the recording zone. 36th Annual meeting for the society

  • XK Chen, TP Williamson, BK Leung, AL Pollock, PA. Tresco
  • 2006
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