Characterization of microRNA expression profiles in Leishmania-infected human phagocytes.

  title={Characterization of microRNA expression profiles in Leishmania-infected human phagocytes.},
  author={Nicholas S. Geraci and Ju Chiat Tan and Mary McDowell},
  journal={Parasite immunology},
  volume={37 1},
Leishmania are intracellular protozoa that influence host immune responses eliciting parasite species-specific pathologies. MicroRNAs (miRNAs) are short single-stranded ribonucleic acids that complement gene transcripts to block protein translation and have been shown to regulate immune system molecular mechanisms. Human monocyte-derived dendritic cells (DC) and macrophages (MP) were infected in vitro with Leishmania major or Leishmania donovani parasites. Small RNAs were isolated from total… CONTINUE READING
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