Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.

@article{Chandrasekharan2002CharacterizationOM,
  title={Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.},
  author={Subhashini Chandrasekharan and Ting Hu Qiu and Nawal W Alkharouf and Kelly Brantley and James B. Mitchell and Edison T. Liu},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 14},
  pages={5235-47}
}
Frk/rak belongs to a novel family of Src kinases with epithelial tissue-specific expression. Although developmental expression patterns and functional overexpression in vitro have associated these kinases with growth suppression and differentiation, their physiological functions remain largely unknown. We therefore generated mice carrying a null mutation in iyk, the mouse homolog of Frk/rak. We report here that frk/rak(-/-) mice are viable, show similar growth rates to wild-type animals, and… CONTINUE READING

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