Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.

@article{Li2006CharacterizationOM,
  title={Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.},
  author={Peng Li and Guang-ji Wang and Jing Li and Haiping Hao and Chao-nan Zheng},
  journal={Journal of mass spectrometry : JMS},
  year={2006},
  volume={41 5},
  pages={670-84}
}
The metabolism of tanshinone IIA was studied in rats after a single-dose intravenous administration. In the present study, 12 metabolites of tanshinone IIA were identified in rat bile, urine and feces with two LC gradients using LC-MS/MS. Seven phase I metabolites and five phase II metabolites of tanshinone IIA were characterized and their molecular… CONTINUE READING