Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes.

@article{Wolz1999CharacterizationOM,
  title={Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes.},
  author={E. Wolz and H. Liechti and Brigitte Notter and G. Oesterhelt and Andreas David Kistler},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 4},
  pages={456-62}
}
The metabolism of the nonprovitamin A carotenoid astaxanthin was investigated in primary cultures of rat hepatocytes. In a time course study based on HPLC and gas chromatography-mass spectrometry analyses, one main metabolite, (rac)-3-hydroxy-4-oxo-beta-ionone, was found. This metabolite was conjugated mainly into glucuronides, as demonstrated by glusulase treatment of the conjugates under sulfatase-inhibiting conditions. Within 24 h more than 50% astaxanthin was metabolized and conjugated… CONTINUE READING
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