Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules.

@article{Guterl2014CharacterizationOM,
  title={Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules.},
  author={Clare Canal Guterl and Olivia M. Torre and Devina Purmessur and Khyati K. Dave and Morakot Likhitpanichkul and Andrew C. Hecht and Steven B. Nicoll and James C Iatridis},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 17-18},
  pages={2536-45}
}
There is an unmet clinical need for a biomaterial sealant capable of repairing small annulus fibrosus (AF) defects. Causes of these defects include painful intervertebral disc herniations, microdiscectomy procedures, morbidity associated with needle puncture injury from discography, and future nucleus replacement procedures. This study describes the enhancements of a fibrin gel through genipin crosslinking (FibGen) and the addition of the cell adhesion molecules (CAMs), fibronectin and collagen… CONTINUE READING

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