Characterization of mammary tumors from Brg1 heterozygous mice

  title={Characterization of mammary tumors from Brg1 heterozygous mice},
  author={Scott J. Bultman and Jason I. Herschkowitz and Virginia Godfrey and Thomas C. Gebuhr and M. Yaniv and Charles M. Perou and Terry Magnuson},
Mammalian SWI/SNF-related complexes have been implicated in cancer based on some of the subunits physically interacting with retinoblastoma (RB) and other proteins involved in carcinogenesis. Additionally, several subunits are mutated or not expressed in tumor-derived cell lines. Strong evidence for a role in tumorigenesis in vivo, however, has been limited to SNF5 mutations that result primarily in malignant rhabdoid tumors (MRTs) in humans and MRTs as well as other sarcomas in mice. We… CONTINUE READING
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