Characterization of macrophage sensitivity and resistance to anthrax lethal toxin.

@article{Friedlander1993CharacterizationOM,
  title={Characterization of macrophage sensitivity and resistance to anthrax lethal toxin.},
  author={Arthur M. Friedlander and Rakesh Bhatnagar and Stephen H Leppla and Leisa Johnson and Yogendra Singh},
  journal={Infection and immunity},
  year={1993},
  volume={61 1},
  pages={245-52}
}
Anthrax lethal toxin, which consists of two proteins, protective antigen and lethal factor, is cytolytic for macrophages. Macrophages from different mouse strains were found to vary in their sensitivities to toxin. C3H mouse macrophages lysed by lethal factor concentrations of 0.001 micrograms/ml were 100,000 times more sensitive than those from resistant A/J mice. We analyzed various stages of the intoxication process to determine the basis for this resistance. Direct binding studies with… CONTINUE READING