Characterization of mRNA interferases from Mycobacterium tuberculosis.

  title={Characterization of mRNA interferases from Mycobacterium tuberculosis.},
  author={Ling Zhu and Y Zhang and Jiah-Shin Teh and Junjie Zhang and Nancy D. Connell and Harvey Rubin and M. Inouye},
  journal={The Journal of biological chemistry},
  volume={281 27},
mRNA interferases are sequence-specific endoribonucleases encoded by the toxin-antitoxin systems in the bacterial genomes. MazF from Escherichia coli has been shown to be an mRNA interferase that specifically cleaves at ACA sequences in single-stranded RNAs. It has been shown that MazF induction in E. coli effectively inhibits protein synthesis leading to cell growth arrest in the quasidormant state. Here we have demonstrated that Mycobacterium tuberculosis contains at least seven genes… CONTINUE READING


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