Characterization of liver function in transdifferentiated hepatocytes.

  title={Characterization of liver function in transdifferentiated hepatocytes.},
  author={Zo{\"e} D. Burke and Chia-Ning Shen and Kate L. Ralphs and David. Tosh},
  journal={Journal of cellular physiology},
  volume={206 1},
We previously demonstrated that dexamethasone (Dex) induces the transdifferentiation (or conversion) of the pancreatic progenitor cell line AR42J-B13 (B13) to hepatocytes based on the expression of liver proteins. We have extended our original observations to determine: (1) the effects of Dex on pancreatic gene expression; (2) the time course of expression of liver enriched transcription factors during conversion from pancreatic to hepatic phenotype; (3) the functional potential of… CONTINUE READING

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