Characterization of ligand binding to immobilized biotinylated extracellular domains of three growth factor receptors.

Abstract

For the purpose of developing a cell-free binding assay suitable for the large scale screening of receptor agonists and antagonists, the extracellular ligand binding domains of the low affinity NGF receptor (p75NGFR), a splicing variant of the fibroblast growth factor receptor (FGFR), and the PDGF beta-receptor (PDGFR) were modified by the biotinylation of… (More)

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