Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.

  title={Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.},
  author={Veerle Baekelandt and Anje Claeys and Kristel Eggermont and Erwin Lauwers and Bart De Strooper and Bart Nuttin and Zeger Debyser},
  journal={Human gene therapy},
  volume={13 7},
Lentiviral vectors are promising tools for gene transfer into the central nervous system. We have characterized in detail transduction with human immunodeficiency virus type 1 (HIV-1)-derived vectors encoding enhanced green fluorescent protein (eGFP) in the adult mouse brain. Different brain regions such as the striatum, hippocampus, and the lateral ventricle were targeted. The eGFP protein was transported anterogradely in the nigrostriatal pathway, but we have found no evidence of transport of… CONTINUE READING


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