Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.

@article{Devlin1990CharacterizationOK,
  title={Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.},
  author={T C Devlin and William J Shoemaker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={253 2},
  pages={749-59}
}
Previous studies of kappa opioid binding sites have suggested heterogeneous binding to this class of opioid receptors. To further investigate kappa receptor heterogeneity, we analyzed the binding properties of various "kappa-selective" ligands in rat brain homogenates. Displacement assays were carried out using [3H]bremazocine in the presence of various displacing ligands under mu and delta receptor-blocked conditions. Homologous displacement of [3H]bremazocine produced "shallow" displacement… CONTINUE READING
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