Characterization of interleukin-1 production by microglia in culture.

  title={Characterization of interleukin-1 production by microglia in culture.},
  author={Jiaiei Yao and Jonette E. Keri and R E Taffs and Carol A. Colton},
  journal={Brain research},
  volume={591 1},
The production of interleukin-1 (IL-1) by cultured neonatal rat microglia was studied using the D10 cell assay. The results show that IL-1 was secreted in response to lipopolysaccharide (LPS) in a dose- and time-dependent fashion. IL-1 production was specific to microglia and was not induced in astrocytes. Indomethacin, which is known to modulate the release of IL-1 from monocytes, had no effect on LPS-stimulated microglia. Aging of the microglia from two weeks to 4 weeks in culture, however… CONTINUE READING

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