Characterization of interactions of enteropathogenic Escherichia coli O127:H6 with mammalian cells in vitro.

@article{Francis1991CharacterizationOI,
  title={Characterization of interactions of enteropathogenic Escherichia coli O127:H6 with mammalian cells in vitro.},
  author={Carol L. Francis and Ann E Jerse and J. Kaper and Stanley Falkow},
  journal={The Journal of infectious diseases},
  year={1991},
  volume={164 4},
  pages={693-703}
}
Previous studies have identified two bacterial factors involved in enteropathogenic Escherichia coli (EPEC) infection. A plasmid-mediated EPEC adherence factor (EAF) is responsible for initial and localized adherence. A chromosomally encoded E. coli attachment and effacement factor (eae) is involved in effacement of the eukaryotic cell surface and characteristic "pedestal" formation. By using isogenic strains deficient in either EAF, eae, or both, the process of EPEC adherence and entry in… CONTINUE READING

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