Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes.

  title={Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes.},
  author={M Hashiramoto and David E. James},
  journal={Molecular and cellular biology},
  volume={20 1},
Insulin regulates glucose transport in muscle and adipose tissue by triggering the translocation of a facilitative glucose transporter, GLUT4, from an intracellular compartment to the cell surface. It has previously been suggested that GLUT4 is segregated between endosomes, the trans-Golgi network (TGN), and a postendosomal storage compartment. The aim of the present study was to isolate the GLUT4 storage compartment in order to determine the relationship of this compartment to other organelles… CONTINUE READING
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