Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium.

@article{LpezBermejo2000CharacterizationOI,
  title={Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium.},
  author={Abel L{\'o}pez-Bermejo and Caroline K Buckway and Gayathri R. Devi and Vivian Hwa and S Stephen R. Plymate and Y. L. Oh and Ron G. Rosenfeld},
  journal={Endocrinology},
  year={2000},
  volume={141 11},
  pages={4072-80}
}
Insulin-like growth factor (IGF)-binding protein (IGFBP)-related proteins (IGFBP-rPs) are newly described cysteine-rich proteins that share significant aminoterminal structural similarity with the conventional IGFBPs and are involved in a diversity of biological functions, including growth regulation. IGFBP-rP1 (MAC25/Angiomodulin/prostacyclin-stimulating factor) is a potential tumor-suppressor gene that is differentially expressed in meningiomas, mammary and prostatic cancers, compared with… CONTINUE READING

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