Characterization of insect neuronal octopamine receptors (OA3 receptors)

  title={Characterization of insect neuronal octopamine receptors (OA3 receptors)},
  author={Thomas Roeder and James A. Nathanson},
  journal={Neurochemical Research},
Octopamine receptors in the nervous tissue of insects were investigated using a ligand-receptor assay with [3H]NC-5Z or [3H]octopamine as the radioligands. Both ligands recognized a homogenous class of binding sites with the properties of an octopamine receptor. This receptor has been characterized pharmacologically. Both high-affinity agonists (e.g. NC 7, K1=0.3 nM) and antagonists (e.g. maroxepine, K1=1.02 nM) were investigated. The neuronal octopamine receptor belongs to a receptor class… 
Octopaminergic agonists for the cockroach neuronal octopamine receptor
Two compounds showed the almost same activity as octopamine in stimulating adenylate cyclase of cockroach thoracic nervous system among 70Octopamine agonists, suggesting that only these compounds are full octopamines agonists and other compounds are partial octopaminergic agonists.
Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors
In future studies on the molecular basis of octopamine signalling in individual tissues it will be essential to identify the relative expression levels of the different classes ofOctopamine receptor present to identify if co-expression of such receptors in the same cells results in the formation of oligomeric receptors with specific emergent pharmacological and signalling properties.
Review of octopamine in insect nervous systems
The roles of OCT in insect nervous systems at the behavioral and molecular levels are described, including the regulation of motivation, desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors, hygiene behavior, and complex social behaviors.
Octopamine-Mediated Neuromodulation of Insect Senses
The main objective of this review is to discuss significance of octopamine-mediated neuromodulation in insect sensory systems.
Tyramine and octopamine: ruling behavior and metabolism.
  • T. Roeder
  • Biology
    Annual review of entomology
  • 2005
Progress made on all levels of OA and TA research has enabled researchers to understand better the molecular events underlying the control of complex behaviors, and these events represent promising targets for new insecticides.
Octopamine and tyramine are structurally related to adrenaline and noradrenaline and have similar physiological roles, which points to an earlyevolutionary origin of the adrenergic/octopaminergic/tyraminergic system.
Identification and characterization of a novel family of Drosophilaβ‐adrenergic‐like octopamine G‐protein coupled receptors
The identification and characterization of a novel, neuronally expressed family of three Drosophila G‐protein coupled receptors that are selectively coupled to increases in intracellular cyclic AMP levels by octopamine are reported on.


Development of a photoaffinity ligand for octopamine receptors.
Octapamine receptors are widely distributed in invertebrate species, yet little is known about their biochemical structure or tissue localization, in part because there exist no high affinity or
Multiple receptor types for octopamine in the locust.
  • P. Evans
  • Biology
    The Journal of physiology
  • 1981
The results are discussed in terms of the location of the various classes of octopamine receptors, their possible relationship to vertebrate alpha‐adrenoreceptors, and the significance of the results for studies on octopamines receptors in the vertebrate central nervous system.
Characterization of octopamine-sensitive adenylate cyclase: elucidation of a class of potent and selective octopamine-2 receptor agonists with toxic effects in insects.
  • J. Nathanson
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1985
Because octopamine-2 receptors appear to be present primarily in invertebrates, these findings raise the possibility that potent and selectiveOctopamine agonists could be useful as insect toxins with low toxicity in vertebrates.
Phenyliminoimidazolidines. Characterization of a class of potent agonists of octopamine-sensitive adenylate cyclase and their use in understanding the pharmacology of octopamine receptors.
Comparison of the relative binding affinities of various PIIs for mammalian alpha-adrenergic receptors, as well as the ability of various antagonists to block PII binding, strongly suggested that the active PIIs are affecting a class of octopamine receptors distinct from mammalian alpha 1- or alpha 2-adRenergic receptors.
Cloning and characterization of a Drosophila tyramine receptor.
The Drosophila tyramine receptor that is isolated might be an invertebrate equivalent of the mammalian alpha 2 adrenergic receptors and share a putative seven transmembrane domain structure.
Octopamine receptors, adenosine 3',5'-monophosphate, and neural control of firefly flashing.
An adenylate cyclase activated as much as 25-fold by low concentrations of octopamine has been identified in the firefly lantern, suggesting a role for adenosine 3',5'-monophosphate (or pyrophosphate) in the neural control of firefly flashing.
Action of formamidine pesticides on octopamine receptors
It is reported here that the formamidine acaricide/insecticide, chlordimeform (CDM), and its demethylated derivative can mimic the actions of octopamine at the locust neuromuscular junction, giving the clearest evidence to date of the site of action of theformamidines and indicates a novel mode of action for these pesticides.
Octopamine in insects: neurotransmitter, neurohormone, and neuromodulator
It is shown that octopamine can act as a neurotransmitter, a neurohormone, and a neuromodulator within the nervous system of invertebrates and in locusts, an identified octopaminergic neuron innervates the extensor-tibiae muscle of the hind legs.
The results suggest that the SR activity is enhanced by octopamine following the onset of flight, and two observations suggest that dorsal unpaired median (DUM) cells are involved in the octopaminergic modulation of the SR during flight.
β-Phenylethylamine, Phenylethanolamine, Tyramine and Octopamine
Phenylethylamine derivatives (Fig. 1) were first synthesized and tested as sympathomimetic compounds (Barger and Dale 1910). Tyramine and octopamine were classified as indirectly acting