Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions.

@article{Lugnier1993CharacterizationOI,
  title={Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions.},
  author={Claire Lugnier and Bernard Muller and Alain Le Bec and Catherine Beaudry and Eric Rousseau},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 3},
  pages={1142-51}
}
The distribution of phosphodiesterase (PDE) activities was studied in canine cardiac microsomal fractions separated by sucrose density gradient (fractions F1 to Fv1). These fractions were characterized by their 45Ca2+ uptake and release properties, [3H] ryanodine binding [used as sarcoplasmic reticulum (SR) markers] and their [3H]nitrendipine binding (as a T-system marker). The solubilized canine and human SR-enriched membranes were subjected to high performance liquid chromatography and the… CONTINUE READING
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