Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry

@article{Hong2021CharacterizationOI,
  title={Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry},
  author={Young-ki Hong and Young-Hoon Kim and Jin-Moo Lee and Hye Hyun Yoo and Sun Ok Choi and Mi Sun Kang},
  journal={International Journal of Legal Medicine},
  year={2021},
  volume={135},
  pages={1471 - 1476}
}
N-Methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine, PAL-1046) is an amphetamine-based new psychoactive substance (NPS). Methamnetamine has been reported to cause excessive release of serotonin, and it is classified as an empathogen or entactogen. It is not regulated as a controlled substance in most countries, and there are no studies on its metabolism. In this study, in vitro phase I metabolism of methamnetamine in human liver microsomes (HLM) and flavin-containing monooxygenase (FMO… 
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Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
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An overview of the metabolic reactions of drugs, natural products, physiological compounds, and other (general) chemicals catalyzed by flavin monooxygenase, monoamine oxidase, NAD(P)H quinone oxidoreductase, and molybdenum hydroxylase enzymes, including roles as substrates, inducers, and inhibitors of the enzymes.
Metabolism testing methods as exemplified by selected new psychoactive substances (NPSs)
TLDR
Alternative methods of metabolism testing for new psychoactive substances (NPSs) are presented and it is shown that by using in vitro methods the metabolism of NPSs can be predicted with high probability.
Suitability of high-resolution mass spectrometry in analytical toxicology: Focus on drugs of abuse

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