Characterization of in vitro chemosensitivity of perioperative human ovarian malignancies by adenosine triphosphate chemosensitivity assay.

@article{Gerhardt1991CharacterizationOI,
  title={Characterization of in vitro chemosensitivity of perioperative human ovarian malignancies by adenosine triphosphate chemosensitivity assay.},
  author={R T Gerhardt and James P. Perras and Bernd U Sevin and Edgar Petru and Ronaldo Ramos and Laura T Guerra and Hervy E. Averette},
  journal={American journal of obstetrics and gynecology},
  year={1991},
  volume={165 2},
  pages={245-55}
}
We report the in vitro chemosensitivity of primary and recurrent human ovarian tumor samples analyzed by adenosine triphosphate chemosensitivity assay. We defined sensitivity as a greater than or equal to 70% decrease in intracellular adenosine triphosphate versus control at 20% of the reported peak plasma concentration per agent tested. Twenty of 21 assays (95.24%) were completed successfully. Single-agent and combined dose-response patterns consisting of decreasing viability with increasing… CONTINUE READING