Characterization of immunotoxins active against ovarian cancer cell lines.

  title={Characterization of immunotoxins active against ovarian cancer cell lines.},
  author={Robert Pirker and David J P Fitzgerald and Thomas C. Hamilton and Robert F. Ozols and W A Laird and Arthur Edward Frankel and Mark C. Willingham and Ira Pastan},
  journal={The Journal of clinical investigation},
  volume={76 3},
The purpose of the present study was to develop immunotoxins directed against human ovarian carcinoma cells. Four monoclonal antibodies (260F9, 454C11, 280D11, and 245E7) were chosen because they were found to bind to various ovarian carcinoma cell lines. These antibodies were covalently linked to either Pseudomonas exotoxin (PE) or ricin A chain (RTA), and the conjugates were tested against five ovarian cancer cell lines (OVCAR-2, -3, -4, -5; A1847). The ability of the immunotoxins to inhibit… CONTINUE READING
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