Characterization of immunotoxins active against ovarian cancer cell lines.

@article{Pirker1985CharacterizationOI,
  title={Characterization of immunotoxins active against ovarian cancer cell lines.},
  author={Robert Pirker and Daniel J. Fitzgerald and Thomas C. Hamilton and Robert F. Ozols and W Laird and Arthur E Frankel and Mark C. Willingham and Ira Pastan},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 3},
  pages={
          1261-7
        }
}
The purpose of the present study was to develop immunotoxins directed against human ovarian carcinoma cells. Four monoclonal antibodies (260F9, 454C11, 280D11, and 245E7) were chosen because they were found to bind to various ovarian carcinoma cell lines. These antibodies were covalently linked to either Pseudomonas exotoxin (PE) or ricin A chain (RTA), and the conjugates were tested against five ovarian cancer cell lines (OVCAR-2, -3, -4, -5; A1847). The ability of the immunotoxins to inhibit… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Immunotoxins against solid tumors

  • Journal of Cancer Research and Clinical Oncology
  • 1988
VIEW 23 EXCERPTS
CITES BACKGROUND & METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Tissue distribution of breast cancer associated antigens defined by monoclonal antibodies

D. Ring
  • J . Biol . Response Modifiers .
  • 1985

Blockade of the galactose - binding sites of ricin by its linkage to antibody : specific cytotoxic effects of the conjugate

R. J. Fulton
  • Eur . J . Biochem .
  • 1984

Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice

D. J. P. FitzGerald, I. S. Trowbridge, I. Pastan
  • 1984

Inhibition of human acute lymphoblastic leukemia cells by immunotoxins : potentiation by chloroquine

A. N. F. Brown, C. D. Myers, A. J. Cumber, B. M. J. Foxwell, J. T. Forrester
  • Science ( Wash . DC ) .
  • 1984