Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders.

@article{Nakahashi2009CharacterizationOI,
  title={Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders.},
  author={Hirotaka Nakahashi and Norifumi Tsukamoto and Yoko Hashimoto and Hiromi Koiso and Akihiko Yokohama and Takayuki Saitoh and Hideki Uchiumi and Hiroshi Handa and Hirokazu Murakami and Yoshihisa Nojima and Masamitsu Karasawa},
  journal={Cancer science},
  year={2009},
  volume={100 4},
  pages={
          671-7
        }
}
The incidence of chronic lymphocytic leukemia is low in the Japanese population compared with populations in western countries, suggesting a role for genetic factors in the occurrence of this disease. We have previously shown that chronic lymphocytic leukemia in Japan rarely expresses the immunoglobulin heavy chain variable region (IGHV) 1-69 gene (1 out of 43 patients, 2.3%), which is a gene most commonly expressed in chronic lymphocytic leukemia cases from western countries. In the current… CONTINUE READING