Characterization of immune responses to baculovirus-expressed equine herpesvirus type 1 glycoproteins D and H in a murine model.

@article{Tewari1994CharacterizationOI,
  title={Characterization of immune responses to baculovirus-expressed equine herpesvirus type 1 glycoproteins D and H in a murine model.},
  author={Devansu Tewari and J. Millar Whalley and Daria N. Love and Hugh J. Field},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 7)},
  pages={1735-41}
}
A murine intranasal infection model for equine herpesvirus type 1 (EHV-1) was used to evaluate immune responses following immunization with insect cells infected by baculoviruses that express EHV-1 glycoproteins. Baculovirus recombinant glycoprotein D (gD) and gH both induced serum antibodies to EHV-1 when measured by ELISA. The gD recombinant also produced a neutralizing antibody response. Protective immunity, determined by accelerated clearance of virus from the target organs in the… CONTINUE READING
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