Characterization of human platelet vascular permeability-enhancing activity.

  title={Characterization of human platelet vascular permeability-enhancing activity.},
  author={Ralph L. Nachman and Babette Weksler and Barbara Ferris},
  journal={The Journal of clinical investigation},
  volume={51 3},
Human platelet acid extract obtained from both whole platelets and from isolated subcellular granules was partially purified by DEAE-cellulose chromatography and Sephadex gel filtration. The heat-stable, nondialyzable cationic protein fraction with a mol wt of approximately 30,000 produced a biphasic increase in vascular permeability in rabbit skin and also had antiheparin activity. The acute (15 min) increase in vascular permeability was blocked by prior treatment of the animal with… CONTINUE READING


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