Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties.

@article{Habersetzer1998CharacterizationOH,
  title={Characterization of human monoclonal antibodies specific to the hepatitis C virus glycoprotein E2 with in vitro binding neutralization properties.},
  author={François Habersetzer and Anne Fournillier and Jean Dubuisson and Domenico Rosa and Sergio Abrignani and Czeslaw Wychowski and I Nakano and Christian Tr{\'e}po and Claude Desgranges and Genevi{\`e}ve Inchausp{\'e}},
  journal={Virology},
  year={1998},
  volume={249 1},
  pages={
          32-41
        }
}
Both linear and conformational determinants of hepatitis C virus (HCV) are believed to be involved in viral neutralization. After immortalization of B cells from HCV chronically infected patients with Epstein-Barr virus, we obtained two polyclonal lymphoblastoid cell lines (LCL) secreting human monoclonal antibodies (HMabs). One clone was derived from a patient infected with a genotype 4 isolate while the second was isolated from a genotype 1b-infected patient. Immunoprecipitation studies… CONTINUE READING

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