Characterization of human monoclonal antibodies directed against hepatitis B surface antigen.

@article{Ehrlich1992CharacterizationOH,
  title={Characterization of human monoclonal antibodies directed against hepatitis B surface antigen.},
  author={Paul H. Ehrlich and Z A Moustafa and J C Justice and K E Harfeldt and Richard. L. Kelley and L G Ostberg},
  journal={Human antibodies and hybridomas},
  year={1992},
  volume={3 1},
  pages={2-7}
}
Four hybridoma cell lines stably secreting human monoclonal antibodies directed against hepatitis B surface antigen have been isolated. The monoclonal antibodies have been characterized by determining several allotypes, measuring affinity for HBsAg, binding to two HBsAg subtypes, and kinetics of antibody binding to solid adsorbed antigen. In addition, the relative position of the epitopes have been determined by competition in binding to HBsAg. The results indicate that human anti-HBsAg… CONTINUE READING
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