Characterization of human iodothyronine sulfotransferases.

  title={Characterization of human iodothyronine sulfotransferases.},
  author={Monique H.A. Kester and Ellen Kaptein and Thirza J Roest and Caren H van Dijk and D Tibboel and Walter Meinl and Heather Glatt and Michael W. H. Coughtrie and Theo J. Visser},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={84 4},
Sulfation is an important pathway of thyroid hormone metabolism that facilitates the degradation of the hormone by the type I iodothyronine deiodinase, but little is known about which human sulfotransferase isoenzymes are involved. We have investigated the sulfation of the prohormone T4, the active hormone T3, and the metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2) by human liver and kidney cytosol as well as by recombinant human SULT1A1 and SULT1A3, previously known as phenol-preferring and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 58 references

The role of sulfation in thyroid hormone metabolism

  • TJ Visser, JCJ van Buuren, M Rutgers, SJ Eelkman Rooda, WW. de Herder
  • Trends Endocrinol Metab
  • 1990
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…