Characterization of human epigenomes.

  title={Characterization of human epigenomes.},
  author={Zhibin Wang and Dustin E. Schones and Keji Zhao},
  journal={Current opinion in genetics & development},
  volume={19 2},
Histone modifications play a key role in regulating transcription and thus ultimately regulate cellular development and differentiation. To understand how histone modifications influence normal development and disease states, a global catalogue of histone modifications and modifying enzymes in normal and disease states is necessary. The first such systematic mapping experiments using the recently developed ChIP-Sequencing technique have revealed a combinatorial modification 'backbone… CONTINUE READING
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