Characterization of human embryonic stem cells with features of neoplastic progression

  title={Characterization of human embryonic stem cells with features of neoplastic progression},
  author={Tamra E Werbowetski-Ogilvie and Marc Boss{\'e} and Morag H. Stewart and Angelique Schnerch and Ver{\'o}nica Ramos-Mej{\'i}a and Anne Rouleau and Tracy Wynder and Mary-Jo Smith and Steve Dingwall and Tim Carter and Christopher Williams and Charles Harris and Joanna A. Dolling and Christopher Wynder and Doug Boreham and Mickie Bhatia},
  journal={Nature Biotechnology},
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers, they may be misconstrued as superior hES cells with enhanced 'stemness'. We characterize two variant hES cell lines (v-hESC-1 and v-hESC-2) that express pluripotency markers at high levels and do… CONTINUE READING


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