Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.

@article{Asokan2006CharacterizationOH,
  title={Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.},
  author={Rengasamy Asokan and Jing Hua and Kendra A. Young and Hannah J Gould and Jonathan P Hannan and Damian M. Kraus and Gerda Szakonyi and Gabrielle J. Grundy and Xiaojiang S. Chen and Mary K Crow and V. Michael Holers},
  journal={Journal of immunology},
  year={2006},
  volume={177 1},
  pages={383-94}
}
Human complement receptor type 2 (CR2/CD21) is a B lymphocyte membrane glycoprotein that plays a central role in the immune responses to foreign Ags as well as the development of autoimmunity to nuclear Ags in systemic lupus erythematosus. In addition to these three well-characterized ligands, C3d/iC3b, EBV-gp350, and CD23, a previous study has identified CR2 as a potential receptor for IFN-alpha. IFN-alpha, a multifunctional cytokine important in the innate immune system, has recently been… CONTINUE READING