Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism.

@article{Sheng2000CharacterizationOH,
  title={Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism.},
  author={Jiqun Sheng and Jiaming Guo and Zhanyong Hua and Michele Caggana and Xinxin Ding},
  journal={Pharmacogenetics},
  year={2000},
  volume={10 8},
  pages={667-78}
}
CYP2G1 is an abundant, olfactory mucosa-specific cytochrome P450 enzyme active in the metabolism of sex steroids and xenobiotic substrates in mammalian animals. Two different human CYP2G genes, CYP2GP1 and CYP2GP2, were characterized in the present study. Polymorphisms in these genes were also studied. CYP2GP1 contained a single nucleotide deletion in exon 2 (deltaC) and a 2.4-kb deletion between exons 3 and 7 (deltaE4-6), whereas CYP2GP2 contained a nonsense mutation in exon 1 and another in… CONTINUE READING