Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice.

Abstract

Humanized mice are crucially important for preclinical studies. However, the development and potential function of human B cells in chimeras remain unclear. Here, we describe the study of human B cells in NOD/LtSzPrkdcscid/J (NOD/SCID) mice. In this study, we transplanted 1.0×10(5) human CD34(+) cells from umbilical cord blood (UCB) into NOD/SCID mice after… (More)
DOI: 10.1016/j.trim.2011.12.003

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