Characterization of human B cell (DK) and promonocyte (U937) clones after HIV-1 exposure: accumulation of viral reverse transcriptase activity in cells and early syncytia induction against SupT1 cells.

@article{Sei1990CharacterizationOH,
  title={Characterization of human B cell (DK) and promonocyte (U937) clones after HIV-1 exposure: accumulation of viral reverse transcriptase activity in cells and early syncytia induction against SupT1 cells.},
  author={Yoshitatsu Sei and Mizue Inoue and Mitchel Mitsuo Yokoyama and J{\'o}zsef B{\'e}k{\'e}si and Prince K. Arora},
  journal={Cellular immunology},
  year={1990},
  volume={125 1},
  pages={1-13}
}
The kinetics of HIV-1 infection were compared among human B (DK), promonocyte (U937), T-B hybrid (CEMX174), and T (H9) cell lines. Just like H9 cells, CEMX174 cells exhibited strong syncytia induction capacity against highly HIV-1-sensitive CD4+ T cells (SupT1) and had high reverse transcriptase (RT) release in the supernatant. DK and U937 cells showed syncytia induction capacity by 72 hr, but RT activity in the culture supernatant (extracellular RT) increased much later. RT activity in cell… CONTINUE READING