Characterization of host genetic expression patterns in HIV-infected individuals with divergent disease progression.

@article{Salgado2011CharacterizationOH,
  title={Characterization of host genetic expression patterns in HIV-infected individuals with divergent disease progression.},
  author={Mar{\'i}a Salgado and Pedro Lopez-Romero and Sergio Callejas and Mariola L{\'o}pez and Pablo Labarga and Ana Dopazo and Vicente Soriano and Berta Rod{\'e}s},
  journal={Virology},
  year={2011},
  volume={411 1},
  pages={103-12}
}
The course of HIV-1 infection shows a variety of clinical phenotypes with an important involvement of host factors. We compare host gene expression patterns in CD3+ T cells from two of these phenotypes: long-term non-progressor patients (LTNP) and matched control patients with standard HIV disease progression. Array analysis revealed over-expression of 322 genes in progressors and 136 in LTNP. Up-regulated genes in progressors were mainly implicated in the regulation of DNA replication, cell… CONTINUE READING
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