Characterization of herpes simplex virus type 1 L-particle assembly and egress in hippocampal neurones by electron cryo-tomography

@inproceedings{Ibiricu2013CharacterizationOH,
  title={Characterization of herpes simplex virus type 1 L-particle assembly and egress in hippocampal neurones by electron cryo-tomography},
  author={Iosune Ibiricu and Ulrike Elisabeth Maurer and Kay Gr{\"u}newald},
  booktitle={Cellular microbiology},
  year={2013}
}
Visualizing virus-host interactions in situ inside infected cells by electron cryo-tomography provides unperturbed snapshots of the infection process. Here we focus on the assembly and egress pathway of herpesviruses. Cells infected with herpes simplex virus 1 produce and release not only infective virions but also non-infectious light particles (L-particles). L-particles are devoid of viral capsids and genomes. In this study, we analysed L-particle assembly and egress pathways in cultured… CONTINUE READING
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