Characterization of hepatitis C virus intergenotypic recombinant strains and associated virological response to sofosbuvir/ribavirin.

@article{Hedskog2015CharacterizationOH,
  title={Characterization of hepatitis C virus intergenotypic recombinant strains and associated virological response to sofosbuvir/ribavirin.},
  author={Charlotte Hedskog and Brian P Doehle and Krishna Chodavarapu and Viktoria Gontcharova and Javier Crespo Garc{\'i}a and Robert de Knegt and Joost P. H. Drenth and John McHutchison and Diana M. Brainard and Luisa M. Stamm and Michael D. Miller and Evguenia S. Svarovskaia and Hongmei Mo},
  journal={Hepatology},
  year={2015},
  volume={61 2},
  pages={471-80}
}
UNLABELLED To date, intergenotypic recombinant hepatitis C viruses (HCVs) and their treatment outcomes have not been well characterized. This study characterized 12 novel HCV recombinant strains and their response to sofosbuvir in combination with ribavirin (SOF/RBV) treatment. Across the phase II/III studies of SOF, HCV samples were genotyped using both the Siemens VERSANT HCV Genotype INNO-LiPA 2.0 Assay (Innogenetics, Ghent, Belgium) and nonstructural (NS)5B sequencing. Among these patient… CONTINUE READING
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