Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil *

  title={Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil *},
  author={Vanessa Salete de Paula and Marcia Leite Baptista and Elisabeth Lampe and Christian Niel and Ana Maria Coimbra Gaspar},
  journal={Journal of Medical Virology},
Hepatitis A virus (HAV) isolates from around the world have been classified into seven genotypes (I–VII). Most human strains belong to genotype I, which has been divided into two subgenotypes, A and B. South America has provided a small number of strains studied at the genome level. In the present study, IgM anti‐HAV antibodies were detected in 116 out of 250 (46%) serum samples collected from consecutive patients with acute hepatitis referred to the Brazilian Reference Center for Viral… 
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Genetic Analysis of Hepatitis A Virus Isolated from Korea
In the present study, the predominant HAV strain in Koreans seemed to be HAV genotype ⅢA, which was reported as a major circulating Hav genotype in Koreans until recently.
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro.
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Genetic characterization of hepatitis A virus isolates from Buenos Aires, Argentina
It is demonstrated that a consistent genetic relatedness of sequences could only be inferred on the basis of a more extensive sequencing of each isolate, and that a co‐circulation of related isolates in neighbor countries was suggested.
Genetic analysis of hepatitis A virus isolates from Brazil
A limited number of hepatitis A virus (HAV) isolates from South America have been characterised at the genomic level, and a Leu → Ile substitution at position 42 in the 2A protein showed a characteristic geographic fingerprint of HAV sequences within Brazil.
Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005–2006
The molecular epidemiology of HAV infection in Korea has changed with the co‐circulation of at least two genotypes and 810Q → S amino acid substitutions were found to be prevalent, suggesting that various HAV strains, including genotype IIIA, might be imported from high‐endemic countries into Korea.
Co-circulation of genotypes IA and IB of hepatitis A virus in Northeast Brazil.
  • L. Villar, L. Morais, A. Gaspar
  • Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2006
This is the first report of co-circulation of sub-genotypes IA and IB in this region, providing additional information about the molecular epidemiology of HAV strains in Brazil.
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Molecular epidemiology of HAV infection in this group of Portuguese appears to be similar to other European countries, and HAV phylogenetic studies can provide important information for the design of appropriate public health measures.
Molecular epidemiology of hepatitis A in St. Petersburg, Russia, 1997–2003
The results indicate the usefulness of molecular epidemiological methods in studying changes in the circulating HAV strains and in tracing transmission routes.
Genetic analysis of HAV strains recovered from patients with acute hepatitis from Southern Italy
The phylogenetic analysis confirms the genetic heterogeneity among HAV strains in Western Europe and suggests that this subgenotype variant circulates also in the Mediterranean area.


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Data presented indicate that in SA there is a circulating population of endemic HAVs from two distinct subgenotypes, with a high degree of conservation was noted between the predicted amino acid sequences from SA clinical isolates and isolates from the rest of the world.
Molecular epidemiology of hepatitis A virus in Amsterdam, the Netherlands *
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Genetic relatedness of hepatitis A virus isolates during a community‐wide outbreak
Analysis of the HAV VP1 amino terminus and VP1/P2A regions showed that a limited number of HAV isolates circulated during the epidemic and the majority of the cases were infected with the same strain.
Genetic relatedness of hepatitis A virus strains recovered from different geographical regions.
A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I to VII), indicating that patterns of endemic transmission can be distinguished from situations in which infections are imported due to travel.
A unique hepatitis A virus strain caused an epidemic in Norway associated with intravenous drug abuse. The Hepatitis A Study Group.
The authors' data indicate different dissemination routes of HAV, suggesting that needle sharing practises contribute to a wide spread of the virus in the IVDA communities, and by early detection of an outbreak, preventive measures can be applied and thereby limit the epidemic at an early stage.
Fecal excretion of Greek strains of hepatitis A virus in patients with hepatitis A and in experimentally infected chimpanzees.
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Direct sequencing of hepatitis A virus strains isolated during an epidemic in France
Direct sequencing of PCR products was used to study the VP1 region of the hepatitis A virus (HAV) genome, and results indicated the existence of two groups of strains belonging to two different subgenotypes (IA and IB).
Epidemiologic patterns of wild-type hepatitis A virus determined by genetic variation.
Investigations indicate that HAV isolates from different parts of the world can be differentiated genetically, which will facilitate studies of epidemiologic transmission.
Hepatitis A in Latin America: a changing epidemiologic pattern.
The need for appropriate vaccination programs to be implemented targeting children, adolescents, and adults, particularly in higher socioeconomic groups is suggested, as data from Brazil, Argentina, and Mexico show that HAV seroprevalence is significantly lower in people living in medium and high socioeconomic conditions.
Molecular epidemiology of human hepatitis A virus defined by an antigen-capture polymerase chain reaction method.
  • R. Jansen, G. Siegl, S. Lemon
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
Virus strains recovered from epidemics of hepatitis A in the United States and Germany were identical in sequence, providing evidence for a previously unrecognized epidemiologic link between these outbreaks.