Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil *

@article{dePaula2002CharacterizationOH,
  title={Characterization of hepatitis A virus isolates from subgenotypes IA and IB in Rio de Janeiro, Brazil *},
  author={Vanessa Salete de Paula and Marcia Leite Baptista and Elisabeth Lampe and Christian Niel and Ana Maria Coimbra Gaspar},
  journal={Journal of Medical Virology},
  year={2002},
  volume={66}
}
Hepatitis A virus (HAV) isolates from around the world have been classified into seven genotypes (I–VII). Most human strains belong to genotype I, which has been divided into two subgenotypes, A and B. South America has provided a small number of strains studied at the genome level. In the present study, IgM anti‐HAV antibodies were detected in 116 out of 250 (46%) serum samples collected from consecutive patients with acute hepatitis referred to the Brazilian Reference Center for Viral… 
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70 Citations

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Elevated identity values were found between isolates obtained in this study and those from other regions of the world, including Brazil, highlighting the high conservation among different isolates of this virus.
Genetic Analysis of Hepatitis A Virus Isolated from Korea
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In the present study, the predominant HAV strain in Koreans seemed to be HAV genotype ⅢA, which was reported as a major circulating Hav genotype in Koreans until recently.
Hepatitis A virus subgenotypes dissemination during a community outbreak in a surrounding region of Rio de Janeiro.
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Multivariate analysis showed that individuals under 20 years old are risks groups to acquire the infection suggesting that hygienic habits of young subjects are the principal factor of transmission and so they could be the target for vaccine programs.
Genetic characterization of hepatitis A virus isolates from Buenos Aires, Argentina
TLDR
It is demonstrated that a consistent genetic relatedness of sequences could only be inferred on the basis of a more extensive sequencing of each isolate, and that a co‐circulation of related isolates in neighbor countries was suggested.
Genetic analysis of hepatitis A virus isolates from Brazil
TLDR
A limited number of hepatitis A virus (HAV) isolates from South America have been characterised at the genomic level, and a Leu → Ile substitution at position 42 in the 2A protein showed a characteristic geographic fingerprint of HAV sequences within Brazil.
Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005–2006
TLDR
The molecular epidemiology of HAV infection in Korea has changed with the co‐circulation of at least two genotypes and 810Q → S amino acid substitutions were found to be prevalent, suggesting that various HAV strains, including genotype IIIA, might be imported from high‐endemic countries into Korea.
Co-circulation of genotypes IA and IB of hepatitis A virus in Northeast Brazil.
  • L. Villar, L. Morais, A. Gaspar
  • Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2006
TLDR
This is the first report of co-circulation of sub-genotypes IA and IB in this region, providing additional information about the molecular epidemiology of HAV strains in Brazil.
Molecular epidemiology of hepatitis A virus in a group of Portuguese citizens living in Lisbon area
TLDR
Molecular epidemiology of HAV infection in this group of Portuguese appears to be similar to other European countries, and HAV phylogenetic studies can provide important information for the design of appropriate public health measures.
Molecular epidemiology of hepatitis A in St. Petersburg, Russia, 1997–2003
TLDR
The results indicate the usefulness of molecular epidemiological methods in studying changes in the circulating HAV strains and in tracing transmission routes.
Genetic analysis of HAV strains recovered from patients with acute hepatitis from Southern Italy
TLDR
The phylogenetic analysis confirms the genetic heterogeneity among HAV strains in Western Europe and suggests that this subgenotype variant circulates also in the Mediterranean area.
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