Characterization of guanylate cyclase activity in single retinal rod outer segments

  title={Characterization of guanylate cyclase activity in single retinal rod outer segments},
  author={Yiannis Koutalos and Kei Nakatani and Takayuki Tamura and King-Wai Yau},
  journal={The Journal of General Physiology},
  pages={863 - 890}
cGMP mediates vertebrate phototransduction by directly gating cationic channels on the plasma membrane of the photoreceptor outer segment. This second messenger is produced by a guanylate cyclase and hydrolyzed by a light-activated cGMP-phosphodiesterase. Both of these enzyme activities are Ca2+ sensitive, the guanylate cyclase activity being inhibited and the light-activated phosphodiesterase being enhanced by Ca2+. Changes in these activities due to a light-induced decrease in intracellular… CONTINUE READING
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